Title : Resveratrol protects dopamine neurons against lipopolysaccharide - induced neurotoxicity through its anti - inflammatory actions
نویسندگان
چکیده
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology (F.Z., H. Z., B. W., J. S. H., and H.-M. G.), National Institute of Environmental Health Sciences/ National Institutes of Health, Research Triangle Park, North Carolina 27709; Shanghai University of Traditional Chinese Medicine (F.Z., J.-S. S.), Shanghai 200071, China; Department of Pharmacology and Key Lab of Basic Pharmacology of Guizhou (F.Z., J.-S. S.), Zunyi Medical College, Zunyi 563003, China Molecular Pharmacology Fast Forward. Published on June 16, 2010 as doi:10.1124/mol.110.064535
منابع مشابه
Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.
Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by a progressive loss of dopamine (DA) neurons in the substantia nigra. Accumulating evidence indicates that inhibition of microglia-mediated neuroinflammation may become a reliable protective strategy for PD. Resveratrol, a nonflavonoid polyphenol naturally found in red wine and grapes, has been known to...
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Resveratrol, a polyphenol compound derived from various edible plants, protects against sepsis-induced acute kidney injury (AKI) via its anti-inflammatory activity, but the underlying mechanisms remain largely unknown. In this study, a rat model of sepsis was established by cecal ligation and puncture (CLP), 30 mg/kg resveratrol was intraperitoneally administrated immediately after the CLP oper...
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Myeloperoxidase (MPO) functions as a key molecular component of the host defense system against diverse pathogens. We have previously reported that increased MPO levels and activity is a distinguishing feature of rotenone-exposed glial cells, and that either overactivation or deficiency of MPO leads to pathological conditions in the brain. Here, we provide that modulation of MPO levels in glia ...
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Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized with a gradual loss of midbrain substantia nigra (SN) dopamine (DA) neurons. An excessive evidence demonstrated that microglia-mediated inflammation might be involved in the pathogenesis of PD. Thus, inhibition of neuroinflammation might possess a promising potential for PD treatment. Icariin (ICA), a si...
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تاریخ انتشار 2010